Treatment of patients with complex vascular anomalies treatment often requires a multidisciplinary approach. The collaboration between a dermatologist, oncologist, radiologist, invasive radiologist, haematologist, plastic surgeon, geneticist, pathologist, neurologist, neurosurgeon, paediatrician, and others is essential for successful treatment.
A multidisciplinary approach is crucial to establish the diagnosis and course of treatment effectively. Pathogenesis of vascular anomalies is influenced by mutations in genes responsible for proper development and function of vascular cells pathogenesis. Vascular anomalies pose not only clinically, but also genetically heterogenous group of congenital anomalies of the vascular system. Clinically, vascular anomalies can present as a single or a mixed vessel anomaly.
Lack of a systematic diagnostic and treatment approach, follow up and misinformation provided to parents of children with vascular anomalies led to the establishment of our Centre for vascular anomalies in 1997. The centre recently provides effective diagnosis, including molecular genetics (Sanger sequencing, Multiplex Ligation-dependent Probe Amplification (MLPA) and next-generation sequencing (NGS), regular follow up and foundation of a data base. Thanks to recent discoveries in molecular diagnostics, we can identify many pathogenic genes in vascular anomalies. Based on these findings we are able to specifically target broad venous and venolymphatic malformations and affect related complications such as pain, functional impairment and chronic coagulopathy.
As mentioned before, the most crucial task of our team is the right pathological and molecular diagnosis, proper treatment initiation and regular follow up. For this reason, we hold regular clinical boards every two weeks to discuss every new potential patient as well as the therapeutical effect of current patients.
Current treatment options of vascular anomalies in our clinic are:
• pharmacological approach (PIK3CA inhibitors, mTOR inhibitors, AKT inhibitors, MAPK inhibitors, VEGF inhibitors
• high power diode laser
• modern sclerotization technique such as embolization
• surgery
• active follow up and family support being important part for all patients
Our highly specialized multidisciplinary team poses unique skills and clinical experience allowing for highly effective diagnostic and treatment options in our paediatric patients with vascular anomalies.
Professor Jaroslav Štěrba, MD., PhD.
spec: pediatrics
subspec.: pediatric oncology
Robert Doušek, MD.
spec.: surgery
subspec.: pediatric surgery
Jana Drochytková, MD.
spec.: dermatovenerology
subspec.: pediatric dermatovenerology
Renata Faberová MD., PhD
spec.: dermatovenerology
subspec.: pediatric dermatovenerology, vascular specialist
Klára Honzíková, MD., PhD.
spec.: dermatovenerology
subspec.: pediatric dermatovenerology
Marta Ježová, MD.
spec.: pathology
subspec.: pediatric pathology
Tomáš Jimramovský, MD.
spec.: pediatrics
subspec.: pediatric neonatology
Jana Kopuletá, MD.
spec.: dermatovenerology
Olga Košková, MD., PhD.
spec.: plastic surgery
subspec.: pediatric plastic surgery
Anna Seehofnerová, MD.
spec.: radiology
subspec.: pediatric radiology
Eva Slouková, MD.
spec.: pediatrics
subspec.: pediatric neonatology
Martin Štěrba, MD.
spec.: pediatrics
subspec.: targeted therapies
Petra Urbanová, MD.
spec.: radiology
Petra Veselá, Mgr.
spec.: genetics
subspec.: molecular genetics
Ondřej Zapletal, MD., PhD.
spec.: pediatrics
subspec: pediatric hematology
