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E-mail:
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Professional experiences:
- 2009 - 2010
Temporary Research Fellow, Mayo Clinic, Rochester, US
Laboratory of Lymphoma Biology (supervisor Prof. T. Witzig, MD and Prof. G. Nowakowski, MD)
Laboratory of CLL Biology (supervisor Prof. C. Zent, MD)
- 2006 - now
Dept of Internal Medicine - Hematooncology, University Hospital Brno
(Research group of As. Prof. S. Pospisilova, PhD and Prof. J. Mayer, MD)
Awards:
- 2010 – Award of the Faculty of Medicine for the most influential scientific publication in 2009
- 2009 - Award of the rector of Masaryk University for the most successful student of PhD programs
- 2008 - Travel Grant provided by the organizing committee of the 13th EHA Congress
- 2009 - Travel Grant provided by the organizing committee of the 14th EHA Congress
- 2009 - Travel Grant provided by the organizing committee of the 51th ASH Annual Meeting
- 2008 - Award „Young Czech Hematologists“-awarded by committee of the Prague Hematology Day
- 2008 - Award for Medicine 2008, awarded by French embassy and Czech Medical Universities
- 2009 - 1st Prize for Young Scientist in Biology and Biochemistry awarded by Sigma - Aldrich
- 2009 - 1st Award for the best presentation of the Leiden International Medical St Conference
Membership:
- European Research Initiative on CLL (ERIC)
- European Hematology Association (EHA)
- European Leukemia Net (ELN)
- Czech Society of Hematology
- Czech Society of Oncology
- Czech Society for Biochemistry and Molecular Biology
- Genetic Society of J.G. Mendel
Peer-Reviewer for Journals:
- Leukemia
- BMC Cancer
- Experimental and Molecular Pathology
- Journal of Nucleic Acid Investigation
- Leukemia and Lymphoma
Teaching activities:
- Faculty of Medicine, Masaryk University, Brno
- Faculty of Sciences, Masaryk University, Brno
Invited speaker at company meetings:
- Life Technologies (Applied Biosystems)
- Sigma-Aldrich
Other activities:
- Reviewer board of American Society of Hematology Annual Meeting
- Instructor at EMBL microRNA workshop (2011)
SELECTED PUBLICATIONS:
- Mraz M,Malinova K, Kotaskova J, Pavlova S, Tichy B, Malcikova J, Stano Kozubik K, Smardova J, Brychtova Y, Doubek M, Trbusek M, Mayer J, Pospisilova S. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia. 2009 Jun;23(6):1159-63.
- Mraz M, Pospisilova S, Malinova K, Slapak I, Mayer J. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes. Leuk Lymphoma. 2009 Mar;50(3):506-9.
- Mraz M, Malinova K, Mayer J, Pospisilova S. MicroRNA isolation and stability in stored RNA samples. Biochem Biophys Res Commun. 2009 Dec 4;390(1):1-4.
- Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, Savvulidi F, Kokavec J, Necas E, Berkova A, Obrtlikova P, Karban J, Mraz M, Pospisilova S, Mayer J, Trneny M, Zavadil J, Stopka T. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. 2011 Feb 4. [Epub ahead of print]
- Kusenda B, Mraz M, Mayer J, Pospisilova S. MicroRNA biogenesis, functionality and cancer relevance. Biomed Pap. 2006 Nov;150(2):205-15.
- Trbusek M, Smardova J, Malcikova J, Sebejova L, Dobes P, Svitakova M, Vranova V, Mraz M, Skuhrova Francova H, Doubek M, Brychtova Y, Kuglik P, Pospisilova S, Mayer J. Missense Mutations Located in Structural p53 DNA-binding Motifs Are Associated with Extremely Poor Survival in Chronic Lymphocytic Leukemia. Journal of Clinical Oncology [in press]
- Mráz M,Pavlová Š, Malčíková J, Malinová K, Mayer J, Pospíšilová, Š. Molekulární patogeneze chronické lymfocytární leukémie. Transfuze a hematologie dnes.2010 Suppl 1: 16-20
- Mráz M,Pospíšilová Š, Mayer J.MicroRNA v patogenezi chronické lymfocytární leukémie a jejich prognostický význam. Transfuze a hematologie dnes. 2010 Suppl 1: 33-35.
Grants:
- Mraz, M.: Grant of the rector of Masaryk University 2007-2008: Analysis of microRNAs in CLL
- Mraz, M.: Grant of the rector of MU 2008-2009: Analysis of expression and function of miRNAs in hematological malignancies
- Dolezalova, D and Mraz, M, M: Grant of the rector of MU 2009-2010: The role of microRNAs and protein coding genes in human embryonic stem cell response to DNA damage
- Pospisilova, S., : Research Grant IGA MZ CR, Internal Grant Agency of the Ministry of Health in the Czech Rep. (Mraz, M-researcher)
- Pospisilova, S., Mraz, M.: Research Grant IGA MZ CR, Internal Grant Agency of the Ministry of Health in the Czech Rep.