The clinical application of precision medicine is very closely linked to translational research, which plays a crucial role in the timely implementation of new scientific results into clinical practice. Therefore, physicians and professionals focusing on precision medicine are often also active researchers who push the boundaries of their fields toward the most advanced diagnostic and therapeutic procedures. In all areas of the application of precision medicine into clinical practice at the University Hospital Brno, whether in precison oncology or rare diseases, also extensive research activities are conducted.