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Prof. MUDr. Zdeněk Ráčil, Ph.D.

Racil

Funkce:

 

 

 

  • vedoucí lékař myeloidního týmu
  • vedoucí lékař pracovní skupiny oportunních infekcí
  • vedoucí lékař separačního střediska
  • ambulantní lékař
 

Telefon:

  • 53223 2144, 2214, 3550
 

E-mail:

 

Tituly:

  • prof., MUDr., Ph.D., Masarykova univerzita Brno
 

Atestace:

  • vnitřní lékařství I. stupně, hematologie a transfúzní služba
 

Klinická orientace:

 

 

 

  • akutní myeloidní leukémie (AML)
  • chronická myeloidní leukémie (CML)
  • Ph negativní myeloproliferativní choroby
  • infekční komplikace u imunokompromitovaných nemocných

Laboratorní orientace:

 

 

 

 

  • molekulární biologie AML, CML
  • klonální evoluce AML, CML
  • farmakokinetika a nežádoucí účinky tyrosinkinázových inhibitorů
  • molekulárně biologická/ sérologická diagnostika invazivních mykotických infekcí
  • farmakokinetika antimykotik

 

Členství v odborných společnostech:

  • Česká hematologická společnost ČLS JEP
  • Česká onkologická společnost ČLS JEP
  • CELL – The Czech Leukemia Study Group for Life
  • European Hematology Association
  • American Society for Microbiology

 

Granty:

  • IGA NR/8452 – 3:  Včasná diagnostika invazivních mykotických infekcí u hematoonkologických nemocných (2005-2007). Hlavní řešitel: prof. MUDr. Ráčil Zdeněk, Ph.D.
  • IGA NS10441-3/2009: Monitorování plazmatických hladin vorikonazolu (2009 – 2011). Hlavní řešitel: prof. MUDr. Ráčil Zdeněk, Ph.D.
  • IGA NS10442-3/2009: Využití nekultivačních metod pro diagnostiku invazivních mykotických infekcí způsobených vláknitými houbami z materiálu získaného bronchoalveolární laváží (2009 – 2011). Hlavní řešitel: prof. MUDr. Ráčil Zdeněk, Ph.D.
  • AZV 15-25809A: Národní program studia mutací a klonality leukemických buněk u pacientů s akutní myeloidní leukémií (2015-2018). Hlavní řešitel: prof. MUDr. Ráčil Zdeněk, Ph.D.

Publikační aktivita:

  • Autor/spoluautor více než 110 publikací
  • Citace (WOS): 508 (bez autocitací)
  • H-index (WOS): 14

Vybrané publikace:

Luong ML, Al-Dabbagh M, Groll AH, Racil Z, Nannya Y, Mitsani D, Husain S. Utility of voriconazole therapeutic drug monitoring: a meta-analysis. J Antimicrob Chemother. 2016 Jul;71(7):1786-99.
 
Culen M, Borsky M, Nemethova V, Razga F, Smejkal J, Jurcek T, Dvorakova D,Zackova D, Weinbergerova B, Semerad L, Sadovnik I, Eisenwort G, Herrmann H, Valent P, Mayer J, Racil Z. Quantitative assessment of the CD26+ leukemic stem cell compartment in chronic myeloid leukemia: patient-subgroups, prognostic impact, and technical aspects. Oncotarget. 2016 May 31;7(22):33016-24.
 
Bezdicek M, Lengerova M, Ricna D, Weinbergerova B, Kocmanova I, Volfova P, Drgona L, Poczova M, Mayer J, Racil Z. Rapid detection of fungal pathogens in bronchoalveolar lavage samples using panfungal PCR combined with high resolution melting analysis. Med Mycol. 2016 Oct 1;54(7):714-24
 
Brhelova E, Kocmanova I, Racil Z, Hanslianova M, Antonova M, Mayer J, Lengerova M. Validation of Minim typing for fast and accurate discrimination of extended-spectrum, beta-lactamase-producing Klebsiella pneumoniae isolates in tertiary care hospital. Diagn Microbiol Infect Dis. 2016 Sep;86(1):44-9.
 
Jeziskova I, Semerad L, Dvorakova D, Janeckova V, Culen M, Kunetkova T, Mayer J, Racil Z. Novel complex mutation in NPM1 gene in patient with acute myeloid leukemia. Leuk Lymphoma. 2016 Aug 3:1-3 
 
Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N,Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G,Santos R, Schwartz S, Vehreschild JJ, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJ; VITAL and FungiScope MucormycosisInvestigators. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016 Mar 8.
 
Ricna D, Lengerova M, Palackova M, Hadrabova M, Kocmanova I, Weinbergerova B,Pavlovsky Z, Volfova P, Bouchnerova J, Mayer J, Racil Z. Disseminated fusariosis by Fusarium proliferatum in a patient with aplastic anaemia receiving primary posaconazole prophylaxis - case report and review of the literature. Mycoses. 2016 Jan;59(1):48-55. doi: 10.1111/myc.12421. Epub 2015 Nov 2. 
 
Sustkova Z, Jeziskova I, Dvorakova D, Horky O, Semerad L, Weinbergerova B,Culen M, Mayer J, Racil Z. Limited efficacy of HLA-haploidentical peripheral blood stem cell infusion in treatment of elderly patients with acute myelogenous leukaemia. Hematol Oncol. 2015 Aug 27. doi: 10.1002/hon.2254. 
 
Jeziskova I, Musilova M, Culen M, Foltankova V, Dvorakova D, Mayer J, Racil Z. Distribution of mutations in DNMT3A gene and the suitability of mutations in R882 codon for MRD monitoring in patients with AML. Int J Hematol. 2015 Nov;102(5):553-7. 
 
Valent P, Sadovnik I, Ráčil Z, Herrmann H, Blatt K, Cerny-Reiterer S, Eisenwort G, Lion T, Holyoake T, Mayer J. DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia. Eur J Clin Invest. 2014 Dec;44(12):1239-45. doi: 10.1111/eci.12368. PubMed PMID: 25371066.
 
Volfova P, Lengerova M, Lochmanova J, Dvorakova D, Ricna D, Palackova M,Weinbergerova B, Mayer J, Racil Z. Detecting human cytomegalovirus drug resistant mutations and monitoring the emergence of resistant strains using real-time PCR.  J Clin Virol. 2014 Oct;61(2):270-4. doi:0.1016/j.jcv.2014.07.008. Epub 2014 Jul 22. PubMed PMID: 25130511.
 
Musilova M, Razga F, Jurcek T, Jeziskova I, Borsky M, Nemethova V, Zackova D, Culen M, Dvorakova D, Mayer J, Racil Z. BCR-ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next-generation sequencing. Am J Hematol. 2014 Oct;89(10):1016-7. doi: 10.1002/ajh.23794. Epub 2014 Jul 22. PubMed PMID: 24984979.
 
Lengerova M, Racil Z, Hrncirova K, Kocmanova I, Volfova P, Ricna D, Bejdak P, Moulis M, Pavlovsky Z, Weinbergerova B, Toskova M, Mayer J. Rapid detection and identification of mucormycetes in bronchoalveolar lavage samples from immunocompromised patients with pulmonary infiltrates by use of high-resolution melt analysis. J Clin Microbiol. 2014 Aug;52(8):2824-8. doi: 10.1128/JCM.00637-14. Epub 2014 May 21. PubMed PMID: 24850354; PubMed Central PMCID: PMC4136189.
 
Jurcek T, Razga F, Mazancova P, Musilova M, Dvorakova D, Borsky M, Zackova D,  Dobesova B, Semerad L, Mayer J, Racil Z. Prospective analysis of low-level BCR-ABL1 T315I mutation in CD34 + cells of patients with de novo chronic myeloid  leukemia. Leuk Lymphoma. 2014 Aug;55(8):1915-7. doi:10.3109/10428194.2013.842988. Epub 2014 Feb 6. PubMed PMID: 24304421.
 
Klampfl T, Milosevic JD, Puda A, Schönegger A, Bagienski K, Berg T,Harutyunyan AS, Gisslinger B, Rumi E, Malcovati L, Pietra D, Elena C, Della Porta MG, Pieri L, Guglielmelli P, Bock C, Doubek M, Dvorakova D, Suvajdzic N, Tomin D, Tosic N, Racil Z, Steurer M, Pavlovic S, Vannucchi AM, Cazzola M, Gisslinger H, Kralovics R. Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2. PLoS One. 2013 Oct 16;8(10):e77819.
 
Racil Z, Razga F, Klamova H, Voglova J, Belohlavkova P, Malaskova L, Potěšil D, Muzik J, Zackova D, Polakova KM, Zdrahal Z, Malakova J, Suttnar J, Dyr J, Mayer J. No clinical evidence for performing trough plasma and intracellular imatinib concentrations monitoring in patients with chronic myelogenous leukaemia. Hematol Oncol. 2013 Aug 20. 
 
Pavlik T, Janousova E, Mayer J, Indrak K, Jarosova M, Klamova H, Zackova D, Voglova J, Faber E, Karas M, Machova Polakova K, Racil Z, Demeckova E, Demitrovicova L, Tothova E, Chudej J, Markuljak I, Cmunt E, Kozak T, Muzik J, Dusek L. Current survival measures reliably reflect modern sequential treatment in CML: Correlation with prognostic stratifications. Am J Hematol. 2013 Jun 11
 
Pagano L, Cornely O, Busca A, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Racil Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, Vehreschild MJ. Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries. Haematologica. 2013 May 28. [Epub ahead of print]
 
Racil Z, Razga F, Drapalova J, Buresova L, Zackova D, Palackova M, Semerad L, Malaskova L, Haluzik M, Mayer J. Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia. Haematologica. 2013 May 28. 
 
Zackova D, Klamova H, Muzik J, Cmunt E, Racil Z, Machova Polakova K, Dvořákova D, Jurcek T, Razga F, Cetkovsky P, Dusek L, Mayer J. Efficacy and tolerance of dasatinib after imatinib failure or intolerance for patients with chronic myeloid leukemia treated in three different hospitals compare well with results achievable in formal clinical trials. Leuk Lymphoma. 2013 Feb 28. 
 
Malcikova J, Razga F, Jurcek T, Dvorakova D, Zackova D, Toskova M, Sebejova L, Smardova J, Oltova A, Vankova G, Jurackova L, Trbusek M, Pospisilova S, Mayer J, Racil Z. The BCR-ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy. Leuk Lymphoma. 2013 Feb 1. 
 
Toskova M, Palousova D, Kocmanova I, Pavlovsky Z, Timilsina S, Lengerova M, Mayer J, Racil Z. Invasive mould disease involving the  gastrointestinal tract caused by Neosartorya pseudofischeri in a haematological patient. Mycoses. 2013; 56(3):385-8.
 
Racil Z, Toskova M, Kocmanova I, Buresova L, Kouba M, Drgona L, Masarova L, Guman T, Tothova E, Gabzdilova J, Forsterova K, Haber J, Ziakova B, Bojtarova E, Rolencova M, Timilsina S, Cetkovsky P, Mayer J. Micafungin as empirical antifungal therapy in hematological patients: a retrospective, multicenter study in the Czech and Slovak Republics. Leuk Lymphoma. 2012 Nov 15. Leuk Lymphoma. 2013;54(5):1042-7.
 
Racil Z, Weinbergerova B, Kocmanova I, Muzik J, Kouba M, Drgona L, Masarova L, Guman T, Tothova E, Forsterova K, Haber J, Ziakova B, Bojtarova E, Vydra J, Mudry P, Foralova R, Sejnova D, Mallatova N, Kandrnal V, Cetkovsky P, Mayer J. Invasive aspergillosis in patients with hematological malignancies in the Czech and Slovak republics: Fungal InfectioN Database (FIND) analysis, 2005-2009. Int J Infect Dis. 2013;17(2):e101-9.
 
Dvorakova D, Racil Z, Borsky M, Robesova B, Jeziskova I, Razga F, Lengerova M, Mayer J. Clonal heterogeneity in patients with cytogenetically normal acute myeloid leukemia with NPM1 mutations. Leuk Lymphoma. 2013;54(5):1056-60
Jeziskova I, Razga F, Toskova M, Dvorakova D, Timilsina S, Mayer J, Racil Z. Quantitative detection of IDH2 mutation for minimal residual disease monitoring in patients with acute myeloid leukemia and its comparison with mutations in NPM1 gene. Leuk Lymphoma. 2013;54(4):867-70
 
Cornelissen JJ, Gratwohl A, Schlenk RF, Sierra J, Bornhäuser M, Juliusson G, Råcil Z, Rowe JM, Russell N, Mohty M, Löwenberg B, Socié G, Niederwieser D, Ossenkoppele GJ. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol. 2012 Oct;9(10):579-90. 
 
Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Am J Hematol. 2012 Nov;87(11):1010-6.
 
Razga F, Jurcek T, Zackova D, Dvorakova D, Toskova M, Jeziskova I, Mayer J, Racil Z. Role of treatment in the appearance and selection of BCR-ABL1 kinase domain mutations. Mol Diagn Ther. 2012 Aug 1;16(4):251-9.
 
Racil Z, Kocmanova I, Toskova M, Winterova J, Lengerova M, Timilsina S, Mayer J. Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study. Mycoses. 2012 May 18. doi: 10.1111/j.1439-0507.2012.02210.x.
 
Volfova P, Lengerova M, Winterova J, Racil Z, Dvorakova D, Mayer J. Monitoring of Epstein-Barr virus load in patients after allogeneic hematopoietic stem cell transplantation. Infection. 2012 Oct;40(5):583-7.
 
Razga F, Jurcek T, Jeziskova I, Zackova D, Dvorakova D, Borsky M, Mayer J, Racil Z. Analysis of mutations in the BCR-ABL1 kinase domain, using direct sequencing: detection of the T315I mutation in bone marrow CD34+ cells of a patient with chronic myelogenous leukemia 6 months prior to its emergence in peripheral blood. Mol Diagn Ther. 2012 Jun 1;16(3):163-6.
 
Racil Z, Winterova J, Kouba M, Zak P, Malaskova L, Buresova L, Toskova M, Lengerova M, Kocmanova I, Weinbergerova B, Timilsina S, Rolencova M, Cetkovsky P, Mayer J. Monitoring trough voriconazole plasma concentrations in haematological patients: real life multicentre experience. Mycoses. 2012 Nov;55(6):483-492.
 
Simara P, Peterkova M, Stejskal S, Potesilova M, Koutna I, Racil Z, Razga F, Jurcek T, Dvorakova D, Mayer J. BCR-ABL activity measured by 50% inhibitory concentration for imatinib, p-CrkL/CrkL ratio or p-CrkL ratio in CD34+ cells of patients with chronic myeloid leukemia does not predict treatment response. Leuk Lymphoma. 2012 Aug;53(8):1627-9. 
 
Lengerova M, Kocmanova I, Racil Z, Hrncirova K, Pospisilova S, Mayer J,Najvar LK, Wiederhold NP, Kirkpatrick WR, Patterson TF. Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection. J Clin Microbiol. 2012 Mar;50(3):602-8.
 
Racil Z, Toskova M, Dvorakova D, Jeziskova I, Razga F, Buresova L, Timilsina S, Mayer J. Treatment of molecular relapse in patients with acute myeloid leukemia using clofarabine monotherapy. Am J Hematol. 2011 Oct 12.
 
Racil Z, Kocmanova I, Toskova M, Buresova L, Weinbergerova B, Lengerova M, Rolencova M, Winterova J, Hrncirova K, Volfova P, Skrickova J, Mayer J. Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases-the role of factors affecting assay performance. Int J Infect Dis. 2011 Dec;15(12):e874-81.
 
Razga F, Racil Z, Machova Polakova K, Buresova L, Klamova H, Zackova D, Dvorakova D, Polivkova V, Cetkovsky P, Mayer J. The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia. Int J Hematol. 2011 Sep;94(3):303-6. 
 
Racil Z, Buresova L, Brejcha M, Prochazkova J, Zounar R, Timilsina S, Razga F, Toskova M, Cetkovsky P, Mayer J. Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Am J Hematol. 2011 Sep;86(9):800-3. 
 
Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR. Detection and investigation of invasive mould disease. J Antimicrob Chemother. 2011 Jan;66 Suppl 1:i15-24. 
 
Racil Z, Razga F, Polakova KM, Buresova L, Polivkova V, Dvorakova D, Zackova D, Klamova H, Cetkovsky P, Mayer J. Assessment of adenosine triphosphate-binding  cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types. Leuk Lymphoma. 2011 Feb;52(2):331-4. 
 
Dvorakova D, Racil Z, Jeziskova I, Palasek I, Protivankova M, Lengerova M, Razga F, Mayer J. Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations. Am J Hematol. 2010 Dec;85(12):926-9. 
 
Jeziskova I, Razga F, Bajerova M, Racil Z, Mayer J, Dvorakova D. IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are  linked to disease status. Leuk Lymphoma. 2010 Dec;51(12):2285-7. 
 
Zackova D, Klamova H, Dusek L, Muzik J, Polakova KM, Moravcova J, Jurcek T, Dvorakova D, Racil Z, Pospisil Z, Oltova A, Michalova K, Brezinova J, Razga F, Doubek M, Cetkovsky P, Trneny M, Mayer J. Imatinib as the first-line treatment of patients with chronic myeloid leukemia diagnosed in the chronic phase: can wecompare real life data to the results from clinical trials? Am J Hematol. 2011  Mar;86(3):318-21.
 
Hrncirova K, Lengerova M, Kocmanova I, Racil Z, Volfova P, Palousova D, Moulis M, Weinbergerova B, Winterova J, Toskova M, Pospisilova S, Mayer J. Rapid  detection and identification of mucormycetes from culture and tissue samples by use of high-resolution melt analysis. J Clin Microbiol. 2010 Sep;8(9):3392-4.
 
Racil Z, Razga F, Buresova L, Jurcek T, Dvorakova D, Zackova D, Timilsina S,  Cetkovsky P, Mayer J. The assessment of human organic cation transporter 1 (hOCT1) mRNA expression in patients with chronic myelogenous leukemia is affected by the proportion of different cells types in the analyzed cell population. Am J  Hematol. 2010 Jul;85(7):525-8.
 
Racil Z, Kocmanova I, Lengerova M, Weinbergerova B, Buresova L, Toskova M, Winterova J, Timilsina S, Rodriguez I, Mayer J. Difficulties in using 1,3-{beta}-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies--high frequency of false-positive results and their analysis. J Med Microbiol. 2010 Sep;59(Pt 9):1016-22. 
 
Racil Z, Kocmanova I, Weinbergerova B, Toskova M, Winterova J, Lengerova M, Buresova L, Timilsina S, Mayer J. Mucositis does not lead to false-positivity of  the Platelia Aspergillus enzyme-linked immunosorbent assay. Eur J Clin Microbiol  Infect Dis. 2010 Jul;29(7):851-5. Epub 2010 Apr 30. PubMed PMID: 20428909
 
Racil Z, Klamova H, Voglova J, Faber E, Razga F, Zackova D, Buresova L, Cetkovsky P, Mayer J. Persistent splenomegaly during imatinib therapy and the definition of complete hematological response in chronic myelogenous leukemia. Am J Hematol. 2010 May;85(5):386-9. 
 
Racil Z, Kocmanova I, Lengerova M, Winterova J, Mayer J. Intravenous PLASMA-LYTE as a major cause of false-positive results of platelia Aspergillus test for galactomannan detection in serum. J Clin Microbiol. 2007Sep;45(9):3141-2. 
 

 

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